Scientific Papers

  • 2012

  • M. Sun*, B. Schwalb*, D. Schulz*, N. Pirkl, S. Etzold,  L. Larivière,  K.C. Maier,  M.Seizl,  A. Tresch, and P. Cramer

    *contributed equally

    Comparative Dynamic Transcriptome Analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation

    Genome Res.Published in Advance March 30, 2012, doi:10.1101/gr.130161.111

    Link

  • B. Treutlein, A. Muschielok, J. Andrecka, A. Jawhari, C. Buchen, D. Kostrewa, F. Hög, P. Cramer, and J. Michaelis

    Dynamic Architecture of a Minimal RNA Polymerase II Open Promoter Complex

    Molecular Cell. 15 March 2012

    Link

  • C. Walmacq, A.C.M. Cheung, M.L. Kireeva, L. Lubkowska, C. Ye, D. Gotte, J.N. Strathern, T. Carell, P. Cramer, and M. Kashlev

    Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage

    Molecular Cell, 08 March 2012

    Link

  • S. Jennebach, F. Herzog, R. Aebersold, and P. Cramer

    Crosslinking-MS analysis reveals RNA polymerase I domain architecture and basis of rRNA cleavage.

    Nucleic Acids Res. 2012 Mar 6. [Epub ahead of print]

    Link

  • A. Vannini and P. Cramer

    Conservation between the RNA Polymerase I, II, and III Transcription Initiation Machineries.

    Molecular Cell, Volume 45, Issue 4. 2012 Feb 24

    Link

    L. Larivière, M. Seizl, and Cramer P.

    A structural perspective on Mediator function.

    Current Opinion in Cell Biology. 2012 Feb 15. [Epub ahead of print]

    Link

  • A. Mayer, A. Schreieck, M. Lidschreiber, K. Leike, D.E. Martin, and P. Cramer

    The Spt5 C-terminal region recruits yeast 3'-RNA cleavage factor I.

    Mol Cell Biol. 2012 Jan 30. [Epub ahead of print]

    Link

  • B. Schwalb, D. Schulz, M. Sun, B. Zacher, S. Dümcke, D.E. Martin, P. Cramer, and A. Tresch.

    Measurement of genome-wide RNA synthesis and decay rates with Dynamic Transcriptome Analysis (DTA).

    Bioinformatics. 2012 Jan 28. [Epub ahead of print]

    Link

  • T. Wild & P. Cramer

    Biogenesis of multisubunit RNA polymerases

    Trends Biochem Sci. 2012 Jan 17. [Epub ahead of print]

    Link

  • 2011

  • T. Koschubs, S. Dengl, H. Duerr, K. Kaluza, G. Georges, C. Hartl, S. Jennewein, M. Lanzendoerfer, J. Auer, A. Stern, K.S. Huang, K. Packman, U. Gubler, D. Kostrewa, S. Ries, S. Hansen, U. Kohnert, P. Cramer and O. Mundigl

    Allosteric antibody inhibition of human Hepsin protease.

    Biochem J. 2011 Dec 2. [Epub ahead of print]

    Link

  • Patrick Cramer and Cynthia Wolberger

    Editorial Preview - Proteins: histones and chromatin

    Current Opinion in Structural Biology 2011, 21:1–3

    Link

  • M. Seizl*, H. Hartmann*, F. Hög*, F. Kurth, D.E. Martin, J. Söding, and P. Cramer

    A Conserved GA Element in TATA-Less RNA Polymerase II Promoters.

    * These authors contributed equally

    PLoS ONE 6(11):e27595

    Link

  • A. C. M. Cheung, S. Sainsbury and P. Cramer

    Structural basis of initial RNA polymerase II transcription

    EMBO J. Epub 2011 Nov 4.

    Link

  • R. Ringel, M. Sologub, Y.I. Morozov, D. Litonin, P. Cramer*, and D. Temiakov*
    Structure of human mitochondrial RNA polymerase.
    *corresponding authors
    Nature. 2011 Sep 25 [Epub ahead of print]

    Link

  • C. Blattner, S. Jennebach, F. Herzog, A. Mayer, A.C. Cheung, G. Witte, K. Lorenzen, K.-P. Hopfner, A.J.R. Heck, R. Aebersold, and P. Cramer
    Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth
    Genes Dev. September 22, 2011 [Epub ahead of print]

    Pol1-RRN3 Model

    Link

  • S.R. Geiger, T. Böttcher, S.A. Sieberand P. Cramer.
    A Conformational Switch Underlies ClpP Protease Function.
    Angew Chem Int Ed Engl. 2011 Jun 14;50(25):5749-52.

    Link

  • M. Müller, R.G. Heym, A. Mayer, K. Kramer, M. Schmid, P. Cramer, H. Urlaub, R.-P. Jansen and D. Niessing.
    A Cytoplasmic Complex Mediates Specific mRNA Recognition and Localization in Yeast.
    PLoS Biology 9(4), 19 Apr 2011.

    Link

  • E. Czeko, M. Seizl, C. Augsberger, T. Mielke, and Patrick Cramer.
    Iwr1 Directs RNA Polymerase II Nuclear Import.
    Mol Cell 42, 261-266 (2011).

    Link

  • M. Seizl, L. Larivière, T. Pfaffeneder, L. Wenzeck, and Patrick Cramer.
    Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization.
    Nucleic Acids Res, 2011 Aug;39(14):6291-304. Epub 2011 Apr 15.

    Link

  • W. Ruan, E. Lehmann, M. Thomm, D. Kostrewa & Patrick Cramer.
    Evolution of two modes of intrinsic RNA polymerase transcript cleavage.
    JBC. 2011 May 27;286(21):18701-7. Epub 2011 Mar 23.

    Link

  • F.W. Martinez-Rucobo, S. Sainsbury, A.C. Cheung, P. Cramer.
    Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity.
    EMBO J. 2011 Apr 6;30(7):1302-10. Epub 2011 Mar 8.

    Model Archeal RNAP-Spt4/5     Model Bacterial RNAP-NusG

    Model Yeast PolII-Spt4/5 Elongation complex

    Link

  • E. Vojnic, A. Mourão, M. Seizl, B. Simon, L. Wenzeck, L. Larivière, S. Baumli, K. Baumgart, M. Meisterernst, M. Sattler, P. Cramer.
    Structure and VP16 binding of the Mediator Med25 activator interaction domain.
    Nat Struct Mol Biol. 2011 Apr;18(4):404-9. Epub 2011 Mar 6.

    Link

  • Alan C.M. Cheung & P. Cramer.
    Structural basis of RNA polymerase II backtracking, arrest and reactivation.
    Nature. 2011 Mar 10;471(7337):249-53. Epub 2011 Feb 23.

    Link

  • C. Miller, B. Schwalb, K. Maier, D. Schulz, S. Dümcke, B. Zacher, A. Mayer, J. Sydow, L. Marcinowski, L. Dölken, D.E. Martin, A. Tresch & P. Cramer.
    Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast.
    Mol. Sys. Biol. 2011 Jan 4;7:458.

    Link

  • 2010

  • E. Clausing, A. Mayer, S. Chanarat, B. Muller, S.M. Germann, P. Cramer, M. Lisby, and K. Strasser.
    The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress.
    J. Biol. Chem. 2010 Dec 31;285(53):41665-74. Epub 2010 Nov 12.

    he transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress

    Link

  • M. Sun, L. Larivière, S. Dengl, A. Mayer, and P. Cramer.
    A tandem SH2 domain in transcription elongation factor Spt6 binds the phosphorylated RNA polymerase II CTD.
    J. Biol. Chem., 2010 Dec 31;285(53):41597-603. Epub 2010 Oct 6.

    Link

  • A. Vannini, R. Ringel, A.G. Kusser, O. Berninghausen, G.A. Kassavetis, and P. Cramer.
    Contributed equally.
    Molecular basis for RNA polymerase III transcription repression by Maf1.
    Cell 143, 59-70 (2010).

    Link

  • A. Mayer, M. Lidschreiber, M. Siebert, K. Leike, J. Söding, and P. Cramer.
    Uniform transitions of the general RNA polymerase II transcription complex.
    Nature Struct. Mol. Biol. 17, 1272-1278 (2010).

    Link

  • S.R. Geiger, K. Lorenzen, A. Schreieck, P. Hanecker, D. Kostrewa, A.J. Heck, and P. Cramer.
    RNA Polymerase I Contains a TFIIF-Related DNA-Binding Subcomplex.
    Mol. Cell 39, 583-594 (2010).

    Link

  • K. Beck, A. Vannini, P. Cramer P, and G. Lipps.
    The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis.
    Nucleic Acids Res, 2010 Oct 1;38(19):6707-18.

    Link

  • P. Cramer.
    Towards molecular systems biology of gene transcription and regulation.
    Biol Chem. 391, 731-735 (2010).

    Link

  • A. Hirtreiter, G.E. Damsma, A.C. Cheung, D. Klose, D. Grohmann, E. Vojnic, A.C. Martin, P. Cramer P, and F. Werner.
    Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif.
    Nucleic Acids Res 38, 4040-4051 (2010).

    Link

  • T. Koschubs, K. Lorenzen, S. Baumli, S. Sandström, A.J.R. Heck, and P. Cramer.
    Contributed equally.
    Preparation and topology of the Mediator middle module.
    Nucleic Acids Res 38, 3186-3195 (2010).

    Link

  • Z.A. Chen, A. Jawhari, L. Fischer, C. Buchen, S. Tahir, T. Kamenski, M. Rasmussen, L. Lariviere, K.C. Bukowski-Wills, M. Nilges, P. Cramer, and J. Rappsilber.
    Architecture of the RNA polymerase II-TFIIF complex revealed by cross-linking and mass spectrometry.
    EMBO J 29, 717-726 (2010).

    Link

  • 2009

  • J.F. Sydow, and P. Cramer.
    RNA polymerase fidelity and transcriptional proofreading.
    Curr Opin Struct Biol 19, 1-8 (2009).

    Link

  • P. Cramer and E. Arnold.
    Editorial - Proteins: how RNA polymerases work.
    Curr Opin Struct Biol 19, 1-3 (2009).

    Link

  • D. Kostrewa, M.E. Zeller, K.J. Armache, M. Seizl, K. Leike, M. Thomm, and P. Cramer.
    Contributed equally.
    RNA polymerase II-TFIIB structure and mechanism of transcription initiation.
    Nature 462, 323-330 (2009).
    Model1 Model2
    (BUSTER electron density map for PDB 3KF1 available upon request)

    Link

  • G.E. Damsma, and P. Cramer.
    Molecular basis of transcriptional mutagenesis at 8-oxoguanine.
    J. Biol. Chem. 284, 31658-63.

    Link

  • J. Andrecka , B. Treutlein, A. Muschielok, R. Lewis, A.C.M. Cheung, P. Cramer. and J. Michaelis
    Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex.
    Nucleic Acids Res 17, 5803-9 (2009).

    Link

  • J.F. Sydow, F. Brueckner, A.C.M. Cheung, G.E. Damsma, S. Dengl, E. Lehmann, D. Vassylyev, and P. Cramer.
    Structural Basis of Transcription: Mismatch-Specific Fidelity Mechanisms and Paused RNA Polymerase II with Frayed RNA.
    Molecular Cell 34, 710-721 (2009).

    Link

  • S. Dengl, and P. Cramer.
    The torpedo nuclease Rat1 is insufficient to terminate RNA polymerase II in vitro.
    JBC 284, 21270-9 (2009).

    Link

  • F. Brueckner, J. Ortiz, and P. Cramer.
    A movie of the RNA polymerase nucleotide addition cycle.
    Curr Opin Struct Biol. 19, 294-299 (2009).

    Link

  • S. Dengl, A. Mayer, M. Sun, and P. Cramer.
    Structure and In Vivo Requirement of the Yeast Spt6 SH2 Domain.
    J. Mol. Biol. 389, 211-225 (2009).

    Link

  • C. Reich, M. Zeller, P. Milkereit, W. Hausner, P. Cramer, H. Tschochner, and M. Thomm.
    The archaeal RNA polymerase subunit P and the eukaryotic polymerase subunit Rpb12 are interchangeable in vivo and in vitro.
    Mol. Microbiol. 71, 989-1002 (2009).

    Link

  • F. Brueckner, K.J. Armache, A. Cheung, G.E. Damsma, H. Kettenberger, E. Lehmann, J. Sydow, and P. Cramer.
    Structure–function studies of the RNA polymerase II elongation complex.
    Acta Cryst. D65, 112-120 (2009).

    Link

  • T. Koschubs, M. Seizl, L. Larivière, F. Kurth, S. Baumli, D.E. Martin, and P. Cramer.
    Identification, structure, and functional requirement of the Mediator submodule Med7N/31.
    EMBO J. 28, 69-80, (2009).

    Link

  • 2008

  • A. Muschielok, J. Andrecka, A. Jawhari, F. Brückner, P. Cramer, and J. Michaelis.
    A nano-positioning system for macromolecular structural analysis.
    Nature Methods 5, 965-971 (2008).

    Link

  • A.J. Jasiak, H. Hartmann, E. Karakasili, M. Kalocsay, A. Flatley, E. Kremmer, K. Sträßer, D.E. Martin, J. Söding, and P. Cramer.
    Genome-associated RNA polymerase II includes the dissociable RPB4/7 subcomplex.
    J. Biol. Chem. 283, 26423-7 (2008).

    Link

  • P. Cramer, K.J. Armache, S. Baumli, S. Benkert, F. Brueckner, C. Buchen, G.E. Damsma, S. Dengl, S.R. Geiger, A.J. Jasiak, A. Jawhari, S. Jennebach, T. Kamenski, H. Kettenberger, C.-D. Kuhn, E. Lehmann, K. Leike, J.F. Sydow, and A. Vannini.
    Structure of Eukaryotic RNA Polymerases.
    Annu. Rev. Biophys. 37, 337-352 (2008).

    Link

  • F. Brueckner, and P. Cramer.
    Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation.
    Nature Struct. Mol. Biol. 15, 811-817 (2008).

    Link

  • S.R. Geiger, C.D. Kuhn, C. Leidig, J. Renkawitz and P. Cramer.
    Crystallization of RNA polymerase I subcomplex A14/A43 by iterative prediction, probing and removal of flexible regions.
    Acta Cryst. F64, 413-418 (2008).

    Link

  • S. Mohammed, K. Lorenzen, R. Kerkhoven, B.V. Breukelen, A. Vannini A, P. Cramer, and A.J. Heck.
    Multiplexed Proteomics Mapping of Yeast RNA Polymerase II and III Allows Near-Complete Sequence Coverage and Reveals Several Novel Phosphorylation Sites.
    Analytical Chem. 80, 3584-92 (2008).

    Link

  • L. Larivière, M. Seizl, S. van Wageningen, S. Röther, L. van de Pasch, H. Feldmann, K. Sträßer, S. Hahn, F.C. Holstege, and P. Cramer.
    Contributed equally.
    Structure-system correlation identifies a gene regulatory Mediator submodule.
    Genes Dev. 22, 872-877 (2008).

    Link

  • K.U. Wendt, Weiss M.S., P. Cramer, D.W. Heinz.
    Structures and diseases.
    Nature Struct. Mol. Biol. 15, 117-120 (2008).

    Link

  • A.G. Kusser, M.G. Bertero, S. Naji, T. Becker, M. Thomm, R. Beckmann, and P. Cramer.
    Contributed equally.
    Structure of an archaeal RNA polymerase.
    JMB 376, 303-307 (2008).

    Link

  • J. Andrecka, R. Lewis, F. Brückner, E. Lehmann, P. Cramer, and J. Michaelis J.
    Single-molecule tracking of mRNA exiting from RNA polymerase II.
    Proc Natl Acad Sci USA 105, 135-140 (2008).

    Link

  • 2007

  • C.D. Kuhn, S.R. Geiger, S. Baumli, M. Gartmann, J. Gerber, S. Jennebach, T. Mielke, H. Tschochner, R. Beckmann, and P. Cramer.
    Functional architecture of RNA polymerase I.
    Cell 131, 1260-1272 (2007).

    Link

  • J. Gerber, A. Reiter, R. Steinbauer, S. Jakob, C.D. Kuhn, P. Cramer, J. Griesenbeck, P. Milkereit and H. Tschochner.
    Site specific phosphorylation of yeast RNA polymerase I.
    Nucleic Acids Research 36, 793-802 (2007).

    Link

  • S. Naji, M.G. Bertero, P. Spitalny, P. Cramer and M. Thomm.
    Structure function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement.
    Nucleic Acids Research 36, 676-687 (2007).

    Link

  • T. Carell, P. Cramer, and K.P. Hopfner.
    The chemistry of transcription through damaged DNA and of translesion synthesis at atomic resolution.
    Nucleic Acids Symp. Ser. 51, 103 (2007).

    Link

  • E. Lehmann, F. Brueckner, P. Cramer.
    Molecular basis of RNA-dependent RNA polymerase II activity.
    Nature 450, 445-449 (2007).

    Link

  • G.E. Damsma, A. Alt, F. Brueckner, T. Carell, and P. Cramer.
    Mechanism of transcriptional stalling at cisplatindamaged DNA.
    Nature Struct. Mol. Biol. 14, 1127-33 (2007).

    Link

  • M. Micorescu, S. Grunberg, A. Franke, P. Cramer, M. Thomm, M. Bartlett.
    Archaeal transcription: function of an alternative transcription factor B from Pyrococcus furiosus.
    J Bacteriol. 190, 157-167 (2007).

    Link

  • K. Lorenzen, A. Vannini, P. Cramer, and A.J.R. Heck.
    Structural Biology of RNA Polymerase III: Mass Spectrometry Elucidates Subcomplex Architecture.
    Structure 15, 1237-1245 (2007).

    Link

  • P. Cramer.
    Finding the right spot to start transcription.
    Nature Struct. Mol. Biol. 14, 686-687 (2007).

    Link

  • P. Cramer.
    Extending the Message.
    Nature 448, 142-143 (2007).

    Link

  • E. Kashkina, M. Anikin, F. Brueckner, E. Lehmann, S.N. Kochetkov, W.T. McAllister, P. Cramer, and D. Temiakov.
    Multi-subunit RNA polymerases melt only a single DNA base pair downstream of the active site.
    J. Biol. Chem 282, 21578-82 (2007).

    Link

  • F. Brueckner & P. Cramer.
    DNA photodamage recognition by RNA polymerase II.
    FEBS Lett, May 11 (2007).

    Link

  • F. Brueckner, U. Hennecke, T. Carell, P. Cramer.
    CPD damage recognition by transcribing RNA polymerase II.
    Science 315, 859-62 (2007).

    Link

  • 2006

  • P. Cramer.
    Deciphering the RNA polymerase II structure: a personal perspective.
    Nature Struct. Mol. Biol. 13, 1042-1044 (2006).

    Link

  • P. Cramer.
    Recent structural studies of RNA polymerases II and III.
    Biochem Soc Trans. 34, 1058-61 (2006).

    Link

  • E. Kashkina, M. Anikin, F. Brueckner, R. T. Pomerantz, W. T. McAllister, P. Cramer, and D. Temiakov.
    Template Misalignment in Multisubunit RNA Polymerases and Transcription Fidelity.
    Mol. Cell 24, 257-266 (2006).

    Link

  • L. Lariviere, S. Geiger, S. Hoeppner, S. Röther, K. Sträßer & P. Cramer.
    Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20.
    Nature Struct. Mol. Biol. 13, 895-901 (2006).

    Link

  • P. Cramer.
    Self-correcting messages.
    Science 313, 447-448 (2006).

    Link

  • A. Jasiak, K.-J. Armache, B. Martens, R.-P. Jansen, & P. Cramer.
    Contributed equally.
    Structural biology of RNA polymerase III: C17/25 X-ray structure and 11-subunit enzyme model.
    Mol. Cell 23, 71-81 (2006).

    Link

  • P. Cramer.
    Mechanistic studies of the mRNA transcription cycle.
    Biochem. Soc. Symp. 71, 41-47 (2006).

    Link

  • H. Kettenberger & P. Cramer.
    Fluorescence detection of nucleic acids and proteins in multi-component crystals.
    Acta Cryst. D62,146-150 (2006).

    Link

  • H. Kettenberger, A. Eisenfuehr, F. Brueckner, M. Famulok & P. Cramer.
    Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs.
    Nature Struct. Mol. Biol. 13, 44-48 (2006).

    Link

  • E. Vojnic, B. Simon, B.D. Strahl, M. Sattler & P. Cramer.
    Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription.
    J. Biol. Chem. 281, 13-15 (2006).

    Link

  • 2005

  • S. Hoeppner, S. Baumli & P. Cramer.
    Structure of the Mediator subunit cyclin C and its implications for CDK8 function.
    J. Mol. Biol. 350, 833-842 (2005).

    Link

  • A. Meinhart, T. Kamenski, S. Hoeppner, S. Baumli & P. Cramer. A structural perspective on CTD function. Genes Dev. 19, 1401-1415 (2005).

    Link

  • K.-J. Armache, H. Kettenberger & P. Cramer.
    The dynamic machinery of mRNA elongation.
    Curr. Op. Struct. Biol. 15, 197-203 (2005).

    Link

  • P. Cramer & W. Baumeister.
    Macromolecular assemblages - from molecules o functional modules.
    Curr. Op. Struct. Biol. 15, 185-187 (2005).

    Link

  • S. Baumli, S. Hoeppner & P. Cramer.
    A conserved Mediator hinge revealed in the structure of the MED7/MED21 heterodimer.
    J. Biol. Chem. 280, 18171-18178 (2005).

    Link

  • K.-J. Armache, S. Mitterweger, A. Meinhart & P. Cramer.
    Structures of complete RNA polymerase II and its subcomplex Rpb4/7.
    J. Biol. Chem. 280, 7131-7134 (2005).

    Link

  • 2004

  • H. Kettenberger, K.-J. Armache, P. Cramer.
    Contributed equally
    Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS.
    Mol. Cell 16, 955-965 (2004).

    Link

  • T. Kamenski, S. Heilmeier, A. Meinhart & P. Cramer.
    Structure and mechanism of RNA polymerase II CTD phosphatases.
    Mol. Cell, 15, 399-407 (2004).

    Link

  • A. Meinhart & P. Cramer.
    Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA processing factors.
    Nature 430, 223-226 (2004).

    Link

  • P. Cramer.
    RNA polymerase structure: from core to functional complexes.
    Curr. Op. Genet. Dev. 14, 218-226 (2004).

    Link

  • M. Cikala, O. Alexandrova, C. N. David, M. Proeschel, B. Stiening, P. Cramer and A. Boettgere.
    The phosphatidylserine receptor from Hydrais a nuclear protein with potential Fe(II) dependent oxygenase activity.
    BMC Cell Biology 5, 26 (2004).

    Link

  • P. Cramer.
    Structure and function of RNA polymerase II.
    Adv. Prot. Chem. 67,1-42 (2004).

    Link

  • G. Lipps, A. Weinzierl, G. von Scheven, C. Buchen, P. Cramer.
    Structure of a bifunctional DNA primase/polymerase.
    Nature Struct. Mol. Biol. 11, 157-162 (2004).

    Link

  • 2003

  • A. Meinhart, J. Blobel & P. Cramer.
    An extended winged helix domain in general transcription factor E/IIE?
    J. Biol. Chem. 278, 48267-48274 (2003).

    Link

  • H. Kettenberger, K.-J. Armache & P. Cramer.
    Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage.
    Cell 114, 347-357 (2003).

    Link

  • K.-J. Armache, H. Kettenberger & P. Cramer.
    Architecture of initiation-competent 12-subunit RNA polymerase II.
    Proc. Natl. Ac. Sc. USA 100, 6964-6968 (2003).

    Link

  • A. Meinhart, T.Silberzahn & P. Cramer.
    The mRNA transcription/processing factor Ssu72 is a potential tyrosine phosphatase.
    J. Biol. Chem. 278, 15917-15921 (2003).

    Link

  • 2002

  • P. Cramer.
    Common structural features of nucleic acid polymerases.
    Bioessays 24, 724-729 (2002).

    Link

  • P. Cramer.
    Multisubunit RNA polymerases.
    Curr. Op. Struct. Biol. 12, 89-97 (2002).

    Link

  • D.A. Bushnell, P. Cramer & R.D. Kornberg.
    Structural basis of transcription:??-amanitin RNA polymerase II cocrystal at 2.8 Å resolution.
    Proc. Natl. Ac. Sc. USA 99, 1218-1222 (2002).

    Link

  • 2001

  • F. Michel, M. Soler-Lopez, C. Petosa, P. Cramer, U. Siebenlist, C.W. Müller.
    Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.
    EMBO J. 20, 6080-6090 (2001).

    Link

  • D.A. Bushnell, P. Cramer & R.D. Kornberg.
    Selenomethionine incorporation in yeast RNA polymerase II.
    Structure 9, R11-14 (2001).

    Link

  • A.L. Gnatt, P. Cramer, J. Fu, D.A. Bushnell & R.D. Kornberg.
    Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 Å resolution.
    Science 292, 1876-1882 (2001).

    Link

  • P. Cramer, D.A. Bushnell & R.D. Kornberg.
    Structural basis of transcription: RNA polymerase II at 2.8 Å resolution.
    Science 292, 1863-1876 (2001).

    Link

  • 2000

  • P. Cramer, D.A. Bushnell, J. Fu, A.L. Gnatt, B. Maier-Davis, N.E. Thompson, R.R. Burgess, A.M. Edwards, P.R. David & R.D. Kornberg.
    Architecture of RNA polymerase II and implications for the transcription mechanism.
    Science 288, 640-649 (2000).

    Link

  • 1999

  • P. Cramer, A. Varrot, C. Barillas-Mury, F.C. Kafatos & C.W. Müller.
    Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA.
    Structure 7, 841-852 (1999).

    Link

  • P. Cramer & C.W. Müller.
    A firm hand on NF-?B: structures of the I?B?-NF-?B complex.
    Structure 7, R1-6 (1999).

    Link

  • 1997

  • P. Cramer, C.J. Larson, G.L. Verdine & C.W. Müller.
    Structure of the NF-?B p52 homodimer-DNA complex at 2.1 Å resolution.
    EMBO J. 16, 7078-7090 (1997).

    Link

  • P. Cramer & C.W. Müller.
    Engineering of diffraction-quality crystals of the NF-?B p52 homodimer-DNA complex.
    FEBS Lett. 405, 373-377 (1997).

    Link

  • 1996

  • A.M. Buckle, P. Cramer & A.R. Fersht.
    Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities.
    Biochemistry 35, 4298-4305 (1996).

    Link

  • 1994

  • P. Bergamini, E. Costa, P. Cramer, J.K. Hogg, A.G. Orpen & P.G. Pringle.
    Diastereoselective C-C bond formation by carbene insertion into Pt-CH3 bonds.
    Organometallics 13, 1058-1060 (1994).

    Link

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